Rectal cancer management has evolved significantly. particularly with neoadjuvant treatment strategies. This narrative review examines the development and effectiveness of these therapies for locally advanced rectal cancer (LARC). highlighting the historical quest that led to current neoadjuvant alternatives. https://www.roneverhart.com/Asus-F1400EA-SB34-14-HD-1366x768-Laptop-Intel-Core-i3-1115G4-3-0-GHz-8GB-DDR4-256GB-SSD-Intel-UHD-Graphics-Windows-11-p9785/