Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. caused by progressive loss of motor neurons. Changes are widespread in the subcortical white matter in ALS. Diffusion tensor imaging (DTI) detects pathological changes in white matter fibres in vivo. https://www.chiggate.com/igora-vibrance-4-99-medium-brown-violet-extra-sale/