Passive stiffness of the heart is determined largely by extracellular matrix and titin. which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD). while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy. https://www.roneverhart.com/50-Pack-Red-Biodegradable-Balloons-12-Thickened-Extra-Strong-Eco-friendly-Latex-Helium-Party-Balloons/
HDAC6 modulates myofibril stiffness and diastolic function of the heart
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