For grant proposals the investigator has to include an estimation of sample size . The size of the sample should be adequate enough so that there is sufficient data to reliably answer the research question being addressed by the study. At the very planning stage of the study the investigator has to involve the statistician. https://www.roneverhart.com/NeOn-Zero-Lefty-M390-BLADE-TITANIUM-HANDLE-MRBS-p11472/