Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation. The Spi1/PU. 1 transcription factor is a key regulator of many steps of hematopoiesis. and limits self-renewal of hematopoietic stem cells. https://www.isyeriacilisi.com/product-category/jack-in-the-box/
Jack in the box
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